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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TARDBP All Species: 10.91
Human Site: Y374 Identified Species: 30
UniProt: Q13148 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13148 NP_031401.1 414 44740 Y374 F G S G N N S Y S G S N S G A
Chimpanzee Pan troglodytes XP_001135126 357 37996 S318 G S G N N S Y S G S N S G A A
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q921F2 414 44529 Y374 F G S G N N S Y S G S N S G A
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515386 295 33249 H256 I I K G I S V H I S N A E P K
Chicken Gallus gallus Q5ZLN5 414 44571 Y374 F S S G N N S Y G G S N S G A
Frog Xenopus laevis Q6NU14 291 32937 S252 G Y G G Y D Y S G Y N Y G N Y
Zebra Danio Brachydanio rerio NP_958884 412 44409 N372 T Y S S A N S N Y G S S S A A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392590 466 50438 G414 I G N S G N S G F L S W M N Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q99383 534 59631 R491 G Y G Y N R D R G D R D R N D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.9 N.A. N.A. N.A. 96.1 N.A. N.A. 66.6 95.1 22.7 76 N.A. N.A. 49.5 N.A. N.A.
Protein Similarity: 100 86.2 N.A. N.A. N.A. 98.7 N.A. N.A. 69.5 97.3 38.4 86.4 N.A. N.A. 63 N.A. N.A.
P-Site Identity: 100 13.3 N.A. N.A. N.A. 100 N.A. N.A. 6.6 86.6 6.6 46.6 N.A. N.A. 26.6 N.A. N.A.
P-Site Similarity: 100 33.3 N.A. N.A. N.A. 100 N.A. N.A. 26.6 86.6 20 53.3 N.A. N.A. 33.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 23.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 38.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 12 0 0 0 0 0 0 12 0 23 56 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 12 12 0 0 12 0 12 0 0 12 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 % E
% Phe: 34 0 0 0 0 0 0 0 12 0 0 0 0 0 0 % F
% Gly: 34 34 34 56 12 0 0 12 45 45 0 0 23 34 0 % G
% His: 0 0 0 0 0 0 0 12 0 0 0 0 0 0 0 % H
% Ile: 23 12 0 0 12 0 0 0 12 0 0 0 0 0 0 % I
% Lys: 0 0 12 0 0 0 0 0 0 0 0 0 0 0 12 % K
% Leu: 0 0 0 0 0 0 0 0 0 12 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 % M
% Asn: 0 0 12 12 56 56 0 12 0 0 34 34 0 34 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 12 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12 % Q
% Arg: 0 0 0 0 0 12 0 12 0 0 12 0 12 0 0 % R
% Ser: 0 23 45 23 0 23 56 23 23 23 56 23 45 0 0 % S
% Thr: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % W
% Tyr: 0 34 0 12 12 0 23 34 12 12 0 12 0 0 12 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _